Job Description

Department
ZRC BIOTECH
Job posted on
Dec 13, 2024
Employment type
C-C5-Confirmed-R&D Staff

Protein characterization - Analytical: M.Sc. / M. Tech. (Biochemistry / Biotechnology) with at least 5 years of industrial hands-on experience in protein characterization including HPLC, structural, and biochemical techniques. Sound knowledge in analytical method development, validation, technology transfer activity and scientific report writing skills.
Upstream Process: M.Sc. (Microbiology/Biochemistry/Biotechnology)/ M. Tech. with Biotechnology with 1 to 3 years of hands-on experience in upstream operations like handling mammalian cell culture process and microbial fermentation. Handling equipment such as Bioreactors, CEDEX Bioanalyzer, etc. Capable of performing activities such as handling of mammalian cell lines, cell bank preparation, media scouting and process optimization at shake flasks, small-scale bioreactors and pilot scale bioreactors to improve yields & product quality.Good Documentation skills like SOP, STP etc.


Upstream Process: Ph.D., (Microbiology/Biochemistry/Biotechnology)/ M. Tech. in Biotechnology with more than 10 years of experience. Hands-on experience with upstream process development and process characterization of mammalian and microbial culture. Sound scientific knowledge as well as report writing skills like Process Development Report, Technology Transfer Document and scale up. Should have proven track record to lead a sizeable team.
Downstream processing and Antibody drug conjugate : PhD / M.Sc. / M. Tech. (Biochemistry/ Biotechnology/ Life sciences) with 2 - 8 years' hands-on experience in protein purification techniques like centrifugation, depth filtration, lab scale column purification, ultrafiltration/diafiltration. Handling of equipment's such as AKTA Avant, AKTA Pure, AKTA Pilot, Automatic TFF system, High throughput screening system, Isolator, Membrane chromatography. Capable of performing activities such as resin screening and process optimization for Mab and ADC at small-scale and pilot scale. Good Communication and documentation (SOP /BMR /TTD/purification report) skills etc.
Down Stream Process : PhD / M. Tech./ M.Sc. (Biochemistry/ Biotechnology/ Life sciences/ Biochemical Engineering) with more than 10 years of experience. Hands-on experience with Downstream process development for mammalian and microbial process. Sound scientific knowledge as well as report writing skills like Process Development Report, Technology Transfer Document. Should have proven track record to lead a sizeable team.
In-process analysis and stability group : Ph.D., M.Sc., M. Tech, M. Pharm Biotechnology / Biochemistry or equivalent with 3 - 10 Years of Experience. Candidate should have hands-on experience on HPLC, gel electrophoresis, spectrophotometric, structural and biochemical techniques for biosimilar or novel biological products. Candidate is responsible for development and qualification of analytical methods, in-process analysis during upstream, downstream and drug product process development, degradation / stability studies, excipient analysis, report and protocol writing.
Formulations Group : Ph.D., M.Sc., M. Tech in Biotechnology / Biochemistry or M. Pharm Biotechnology / Pharmaceutics with 3 - 5 Years of Experience. Candidate is responsible for planning and execution of formulation development, stability / degradation studies and technology transfer for biosimilar and novel biological products. Candidate should have hands-on experience on techniques related to liquid and lyophilized formulation development. Candidate is responsible for formulation screening studies, selection of container-closure systems, analysis for formulation screening studies, stability / degradation studies and documentation. Candidate is responsible for drug product manufacturing technology transfer activity to the manufacturing site including execution of the drug product batch manufacturing in collaboration with manufacturing team.
Cell line development, Cell and Gene therapy, Immuno-analytics. Molecular Biology :M. Sc. in any field of life sciences with 3-4 years of experience / Ph.D. in life sciences with hands on experience in molecular biology techniques like PCR, Real-time PCR, Nucleic acid isolation, rDNA techniques, DNA sequencing, in-vitro transcription and in-vitro translation and basic DNA / RNA / Protein analytic tools. Basic knowledge of bioinformatics to handle Molecular Biology analysis tools. Experience in cell and gene therapy development activities like LV/AAV/RV vector constructions, and molecular biology based engineered viral vector and cell characterization. Candidate is required to have good communication and scientific report writing skills.
Mammalian cell culture : M.Sc.(Any Life sciences area) /M.tech / M.Pharm with Biotechnology - Freshers or candidates with 3-5 years of experience in mammalian cell culture such as handling of various cell lines, optimization & execution of stable/ transient transfections, clone screening, media/process optimization at shake flasks & small scale bioreactors to improve yields & quality, cell bank preparations, ELISAs. Basic understanding of DoE tools for media optimizations. Experience in cell and gene therapy development activities like LV/ RV/AAV production, Primary cells (Stem cells/T cells/ NK cells etc) isolation and expansion, cytotoxicity assays, etc.
Upstream analytics: M.Sc. (Any Life sciences area) / M. Tech (Biochemistry/Biotechnology)/M. Pharm -with Biotechnology. Freshers or candidates with 2-4 years' experience in protein binding studies using SPR; purification of therapeutic proteins, antibodies, LVs/AAVs/RVs etc., protein characterization techniques like HPLC, HP-SEC, IEF, IEC, SDS PAGE etc for characterization of Biologics
(Immunoassays):
PK/ PD/ Immunogenicity : MSc. (Any life sciences area) / M. Pharm (Biotechnology/Pharmacology)- Fresher's or candidates with 3-7 years of experience in activities like development, validation & execution of PK/ PD/ Immunogenicity/ Nab assays (ELISA/CLIA/MSD) to support pre-clinical & clinical studies for Biosimilar /New Biologics in a GLP set up, Experience in animal handling, preparation of regulatory documents. Should have scientific understanding of PK/PD/ADA of biologics in animals & humans; knowledge of biostatistics, animal to human dose simulations etc.