Job Description

DMPK (PRE-FORMULATIONS)

RESEARCH SCIENTIST

Educational qualifications



M.Pharm (Pharmaceutics)/ Ph.D (Pharmacy)


Years of experience



8-10 yrs


Key Responsibilities

?



Read and understand client pre-formulation


requirements
?

Solid State and Solution State


Characterization (interpretation of DSC, TGA


and pXRD etc. data)
?

Solubility assessment in Aqueous and


Organic solvents simulated intestinal and


gastric Medias.
?

Bioavailability enhancement of compounds
?

Excipient Compatibility Studies
?

Preclinical formulation development of NCEs


for pharmacokinetic, toxicology, & in vivo


efficacy studies.
?

Ability to work with wide variety of


excipients, API and dosage forms
?

Hands-on experience in strategy to come up


with pharmaceutically acceptable salts for


NCEs and their characterization and


interpretation of the data to propose the


suitable salt.
?

Should know the know-how of various


formulations combinations to address the


solubility issues for various routes to perform


PK studies in preclinical species.
?

Should be able to develop dosage forms for


therapeutic areas like oncology, metabolic


disorders, inflammation etc.
?

Should be able to develop HPLC-UV based


methods for conducting formulation analysis


under GLP and Non-GLP modes
?

Good knowledge of chromatography
?

Preparation of documents such as SOP's for


DMPK (PRE-FORMULATIONS)

RESEARCH SCIENTIST

Laboratory instruments and reports for


preformulation studies.





Experience required

?



Good scientific knowledge about the role of


pre-formulation in small molecule discovery.
?

Basic knowledge of pharmacokinetics .
?

Knowledge of various excipients and their


permissible limits in preclinical and clinical


setups.
?

Handling of HPLC-UV/PDA
?

Liquid chromatography.