Job Description

DMPK (PRE-FORMULATIONS)

RESEARCH ASSOCIATE/ Sr. RESEARCH ASSOCIATE

Educational qualifications

M.Pharm (Pharmaceutics)


Years of experience

3-8 yrs


Key Responsibilities

• Read and understand client pre-formulation

requirements
• Solid State and Solution State

Characterization (interpretation of DSC, TGA
and pXRD etc. data)


• Solubility assessment in Aqueous and Organic

solvents simulated intestinal and gastric
Medias.


• Bioavailability enhancement of compounds
• Excipient Compatibility Studies
• Preclinical formulation development of NCEs

for pharmacokinetic, toxicology, & in vivo


efficacy studies.


• Ability to work with wide variety of excipients,

API and dosage forms
• Hands-on experience in strategy to come up

with pharmaceutically acceptable salts for
NCEs and their characterization and


interpretation of the data to propose the


suitable salt.


• Should know the know-how of various

formulations combinations to address the
solubility issues for various routes to perform


PK studies in preclinical species.


• Should be able to develop dosage forms for

therapeutic areas like oncology, metabolic
disorders, inflammation etc.


• Should be able to develop HPLC-UV based

methods for conducting formulation analysis
under GLP and Non-GLP modes


• Good knowledge of chromatography
DMPK (PRE-FORMULATIONS)

RESEARCH ASSOCIATE/ Sr. RESEARCH ASSOCIATE

• Preparation of documents such as SOP's for

Laboratory instruments and reports for
preformulation studies.


Experience required

• Good scientific knowledge about the role of

pre-formulation in small molecule discovery.
• Basic knowledge of pharmacokinetics .
• Knowledge of various excipients and their

permissible limits in preclinical and clinical


setups.


• Handling of HPLC-UV/PDA
• Liquid chromatography.