Job Description

DMPK (Invitro)

Sr. RESEARCH SCIENTIST

Educational qualifications



Ph.D (Pharmacy)


Years of experience





3-6 yrs





Job Scope / Purpose



Design experiments to understand PK/PD relationships


in various Integrated Drug Discovery Projects. Planning


strategies, work-flow distribution, managing and


prioritizing the projects assigned. Present the results of


the experiments in various project meetings (internal


and external)





Key Responsibilities

?



Understand the broader ADME requirements of


various projects
?

Ability to understand ADME-SAR and guide


chemistry teams towards improving druggability of


the NCEs
?

Design DMPK strategy and implementation plan
?

Conduct PK and PK/PD analysis through early pre-

clinical development, and collaborate in PK/PD and


efficacy study designs.
?

Collaborate with safety assessment group (in need


basis) on study design
?

Interact with other cross functional teams (internal


and external) and contribute to the progression of


the compounds in the project.
?

Design tailor made ADME protocols for various


projects.
?

Collate the obtained results and prepare


presentations for internal and external meetings.
?

Contribute to the design of the critical path for


various projects.
?

Prediction of human pharmacokinetic properties


from in vitro and in vivo data
?

Method validations and analytical trouble shooting;


Data generation, compilation, report preparation;


Lab note book, record keeping; SOP writing
?

Management towards optimising utilization of lab


resources.
?

Keeping a track of FTE utilization in projects
?

Keep track of CAPEX and OPEX requirements of the


lab


DMPK (Invitro)

Sr. RESEARCH SCIENTIST
?

Manage animal house and laboratory instruments


properly
?

Prepare regular project updates and share with


DMPK team management
?

Guide people/team on planning and execution of


work and SOP writing
?

Guide people/team towards developing required


skill set to execute day to day activities in various


projects
?

Mentor juniors and train them on ongoing assays


and technologies
?

Should make sure that team follows ethical


guidelines towards assay validation, data analysis,


recording experiments, updating the data and


maintenance.
?

Ability to communicate the scientific work to peer


reviewed journals.


Behavioral and Soft Skills

?



Should have strong project management and


influencing skills with excellent communication and


presentation skills.
?

Should be able to work with senior leadership teams


on strategy and cross-functional teams.
?

Good attitude to work in a team and help other


members in the team.